The changed functional status of the brain was involved in patients with poststroke aphasia: Coordinate‐based (activation likelihood estimation) meta‐analysis. Issue 12 (6th October 2020)

• Record Type: Journal Article
• Authors: Du, Ying; Lee, Yujun; He, Chuan; Peng, Lihan; Yong, Qian; Cen, Zhiyi; Chen, Yuqin; Liu, Xin; Wang, Xiaoming
• Is Part Of: Brain and behavior. Volume 10:Issue 12(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-10-06
• Subjects: ALE -- aphasia -- meta‐analysis -- rs‐fMRI -- stroke; Neurology -- Periodicals; Neurosciences -- Periodicals; Psychology -- Periodicals; Psychiatry -- Periodicals; 616.8005
• DOI: 10.1002/brb3.1867
• Languages: English
• ISSNs: 2162-3279

Abstract

Abstract: Background and Purpose: Although many functional magnetic resonance imaging (fMRI) studies have investigated the language architecture and neurobiological mechanism underlying poststroke aphasia (PSA), the pathophysiological mechanisms of PSA still remain poorly understood. In addition to a limited number of subjects (<20) tested with different methodologies and stimuli, inconsistent reports of the brain regions involved have been a major factor. Thus, we conducted a meta‐analysis of 12 peer‐reviewed studies of abnormal brain activation regions in PSA patients at rest using activation likelihood estimation (ALE). Results: A meta‐analysis was performed based on 24 experiments with 497 total participants in 12 studies to establish the ALE of regional activation in PSA. Through experiments with PSA patients and healthy controls, we found that hypoactivation in PSA converged on the left superior frontal gyrus and the left parietal postcentral gyrus, whereas there was hyperactivation in the right cerebellar anterior lobe, left fusiform gyrus, left superior parietal lobule, and right subgyral hippocampus. Conclusion: Our study verified that dominant and nondominant language networks play roles in the recovery of language function. Abstract : Although the underlying pathophysiological mechanism of poststroke aphasia (PSA) is greatly concerned, it remains unclear. By coordinate‐based (ALE) meta‐analysis, we found that the activation of the left superior frontal gyrus (SFG) and the parietal postcentral gyrus of PSA presented hypoactivation, while there was hyperactivation in the right cerebellar anterior lobe, fusiform gyrus, superior temporal gyrus (STG), superior parietal lobule (SPL), and subgyral hippocampus. It is worth noting that the changed functional status of area in brain is more involved in right lobe. The future studies on rehabilitation should be given more attention to the right area.