Time intervals from first symptom recognition to pathological diagnosis among patients with oesophageal cancer in Ethiopia: a cross-sectional study. Issue 8 (5th August 2022)

• Record Type: Journal Article
• Authors: Dessalegn, Berhe; Getachew, Sefonias; Yirgu, Robel; Enqueselassie, Fikre; Assefa, Mathewos; Addissie, Adamu
• Is Part Of: BMJ open. Volume 12:Issue 8(2022)
• Publication Date: 2022-08-05
• Subjects: Bone marrow transplantation -- Public health -- Pathology -- Cancer pain -- Oesophageal disease; Medicine -- Research -- Periodicals; 610.72
• DOI: 10.1136/bmjopen-2022-060812
• Languages: English
• ISSNs: 2044-6055

Abstract

Abstract : Objective: The aim of this study was to estimate the time intervals from first symptom recognition to pathological diagnosis among patients with oesophageal cancer in Ethiopia. Methods: Design: A cross-sectional study design was employed. Settings and participants: Patients with oesophageal cancer aged ≥18 years were included from Addis Ababa, Ethiopia (n=338) from February 2019 to August 2020. The participants were selected consecutively from six health facilities that provided cancer care nearly for 90% of patients. Main outcomes and measurements: The Aarhus statement criteria were applied to classify patient intervals (time from first symptom recognition to presentation) and diagnostic intervals (time from first presentation to diagnosis). Patient and diagnostic intervals >60 and >30 days were considered as delays, respectively. For tumour classification, the American Joint Committee on Cancer was used. Data were analysed using SPSS V.24. Descriptive statistics were applied to describe patients' characteristics. Poisson regression with robust variance was used to compute prevalence ratios. In all statistical tests, significance was declared at a p value of <0.05. Results: The mean (SD) age of the participants was 54.30±12.49 years. Approximately 78% of study participants had never heard of oesophageal cancer and thought they had gastritis. Dysphagia was the commonly mentioned symptom. About 76% of the cases were diagnosed at advanced stages (III and IV). Median patient interval was 108.5 (60.5–215) days and median diagnostic interval was 77.5 (39–133) days. After adjusting confounders, being single and unawareness of oesophageal cancer had association with consultation delay; cost of transportation and medical consultation had association with diagnostic delay; and patient delay of >2 months had association with late-stage diagnosis. Conclusion: Patients with oesophageal cancer in Ethiopia had prolonged patient and diagnostic intervals. Increasing awareness of symptoms of oesophageal cancer and shortening time to diagnosis will help to improve the outcome of oesophageal cancer care in Ethiopia.