Associations between the Patient Perception of Bladder Condition score and overactive bladder syndrome symptoms at baseline and upon treatment. Issue 6 (20th May 2022)

• Record Type: Journal Article
• Authors: Schönburg, Sandra; Murgas, Sandra; Fornara, Paolo; Michel, Martin C.
• Is Part Of: Neurourology and urodynamics. Volume 41:Issue 6(2022)
• Page Start: 1399
• Page End: 1405
• Publication Date: 2022-05-20
• Subjects: nonparametric analysis -- overactive bladder syndrome -- patient perception of bladder condition -- symptom score; Urinary organs -- Periodicals; Urodynamics -- Periodicals; Urology -- Periodicals; 616.6
• DOI: 10.1002/nau.24960
• Languages: English
• ISSNs: 0733-2467

Abstract

Abstract: Background: Patient‐reported outcomes such as the Patient Perception of Bladder Condition (PPBC) score are frequently used to characterize overactive bladder syndrome (OAB) patients and their treatment outcomes. However, little information is available on the relationship of such scores to OAB symptoms at the individual patient level. Methods: We have performed a post hoc analysis of two large noninterventional studies ( n = 1345 and 745) in which patients received propiverine extended release (30 or 45 mg/day) for 12 weeks to determine the strength of nonparametric correlations between PPBC and OAB symptoms at baseline, after treatment and with treatment‐associated changes thereof. Results: PPBC was not correlated with age but with episode frequencies of urgency, incontinence, micturitions, and nocturia, but the strength of correlations was only moderate (Spearman rank correlation coefficient 0.2045−0.3553). Similarly moderate correlations were observed after treatment and when changes in PPBC were compared to those of OAB symptoms, although these correlations were somewhat stronger. Conclusions: PPBC is only moderately correlated to OAB symptoms indicating that it characterizes patients beyond what is captured by their symptoms.