Low serum albumin at admission is a predictor of early colectomy in patients with moderate to severe ulcerative colitis. Issue 3 (16th February 2021) - Tanaka, Makoto
Abstract: Background and Aim: Several studies have identified postinduction therapy predictors of long‐term outcomes of ulcerative colitis (UC) in patients who experienced the first attack of the disease or relapsed after therapy. We aimed to identify the preinduction therapy predictors at admission that predicted early colectomy in patients with moderate to severe UC. Methods: Ninety‐five patients with moderate to severe UC who underwent induction therapy at the Kyoto Prefectural University of Medicine hospital between August 2008 and March 2020 were retrospectively included and categorized into two groups: the colectomy group ( n = 27) and the noncolectomy group ( n = 68). The clinical parameters (age, gender, disease extent, and disease activity on admission), induction therapies administered [including 5‐aminosalicylic acid, steroids, immunomodulators, calcineurin inhibitor, and anti‐Tumor Necrosis Factor (TNF)‐α antibodies], and laboratory data (hemoglobin, albumin, C‐reactive protein, and cytomegalovirus reactivation on admission) were evaluated and compared between the two groups. Multivariate logistic regression analyses were performed to identify significant predictors of early colectomy, and P < 0.05 was considered significant. Results: All clinical parameters were not significant predictors of colectomy. Among laboratory parameters, the serum albumin level on admission was a significant independent predictor of colectomy (odds ratio: 6.097, 95% confidence interval: 1.8310–20.3047). Receiver operating characteristic curves were plotted for the serum albumin levels of the 95 patients at admission. The cut‐off value of serum albumin was 2.45 g/dL. Conclusions: When the serum albumin level of UC patients at admission is below 2.45 g/dL, we should consider presenting the option of surgical treatment to patients. Abstract : We investigated the pre‐induction therapy predictors at admission that predicted early colectomy in patients with moderate to severe UC. UC patients were retrospectively categorized into the colectomy group and the non‐colectomy group, and clinical parameters, induction therapy administered, and laboratory data were compared between these two groups. Low serum albumin level (less than 2.45 g/dL) on admission were identified to be significant independent predictors of colectomy.