E-002 Intracranial aneurysm clinical trials: trends of developing treatments in the last two decades. (23rd July 2022)

• Record Type: Journal Article
• Authors: Klein, J; Shlobin, N; Nandoliya, K; Jahromi, B; Potts, M
• Is Part Of: Journal of neurointerventional surgery. Volume 14(2022)Supplement 1
• Page Start: A74
• Page End: A74
• Publication Date: 2022-07-23
• Subjects: Nervous system -- Surgery -- Periodicals; Cerebrovascular disease -- Surgery -- Periodicals; 617.48
• DOI: 10.1136/neurintsurg-2022-SNIS.113
• Languages: English
• ISSNs: 1759-8478

Abstract

Abstract : Introduction: Innovative technologies continue to improve interventional and surgical treatment of intracranial aneurysms, improving the safety and efficacy of interventions. Understanding clinical trial trends related to the treatment of intracranial aneurysms provides insight into future practice developments. Materials and Methods: Using the general search term 'aneurysm' and other relevant filters, all clinical trials related to treatment of intracranial aneurysm registered in Clinicaltrials.gov from the past 20 years (January 1, 2001 to September 30th, 2021) were categorized and reviewed. Results: We identified 1623 trials relating to cerebral aneurysms, of which 17% focused on cerebral aneurysm treatments. These studies occurred across 30 countries - most frequently in the United States (35%), followed by China (16%), France (12%), and Germany (8%). More than half (57%) were multi-centered. Twenty-four percent involved surgical clipping, 52% coil embolization, 23% flow-diversion, and 23% drug therapy. Recent aneurysmal hemorrhage was a selection criterion in 20%. The number of trials increased over the two included decades from 52 in 2000–2010 to 221 in 2011–2021. The percentage of endovascular device studies increased across decades (44% versus 57%), with a notable increase in studies involving flow diversion (12% versus 25%, p=0.03). Conversely, the percentage of surgical clipping and drug trials both decreased (27% to 23% and 29% to 22%, respectively). A total of 80 linked publications were identified for the included trials, of which 51 were concluded as having a positive result in line with the study hypothesis. Conclusions: The field of cerebral aneurysm treatment has seen a marked increase in clinical trials over the past two decades. This trend is largely attributable to the study of endovascular devices, especially those involving flow diversion. Disclosures: J. Klein: None. N. Shlobin: None. K. Nandoliya: None. B. Jahromi: None. M. Potts: None.