E-155 Impact of pre-treatment cerebral microbleeds on hemorrhagic transformation following successful recanalization by endovascular treatment in patient with acute ischemic due to large artery occlusion. (23rd July 2022) - Kim, J
Abstract : Background and Purpose: We analyzed the association between pretreatment cerebral microbleeds (CMBs) and hemorrhagic transformation (HT) after successful recanalization by endovascular treatment (EVT) in patients with acute ischemic stroke due to large vessel occlusion (LVO). Methods: A total of 116 acute ischemic stroke patients successfully recanalized by EVT for emergent LVO were enrolled in this prospective cohort study. CMBs and hemorrhagic transformation on T2*-MRI using a validated scale were rated by an experienced neuroradiologist. The primary outcome was hemorrhagic transformation after EVT. We investigated association of CMB presence and burden with HT. The secondary outcome was defined as poor functional outcome with modified Rankin Scale scores at 3 months of 3 to 6. Results: Among 116 patients (mean age 66.2±14.0, male 78%), 18 (15.7%) had CMBs and 52 (45.2%) had HT. There was statistically significant association between the presence of CMB and HT after EVT in patients with successful recanalization (77.8% versus 3.1%; P =0.003). The presence or number of CMBs was not associated with poor functional outcomes. Conclusions: These results indicate that the presence of CMBs were related to HT after EVT. However, there is no impact of pre-treatment of CMBs on poor functional outcome in patients with successful recanalization by EVT. Disclosures: J. Kim: None. S. Lee: None. S. Chung: None. I. Yu: None.