Linear and nonlinear identification of the carotid sinus baroreflex in the very low‐frequency range. Issue 14 (20th July 2022)

• Record Type: Journal Article
• Authors: Kawada, Toru; Miyamoto, Tadayoshi; Mukkamala, Ramakrishna; Saku, Keita
• Is Part Of: Physiological reports. Volume 10:Issue 14(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-07-20
• Subjects: arterial baroreflex -- Gaussian white noise -- transfer function -- Uryson model; Physiology -- Periodicals; 571
• DOI: 10.14814/phy2.15392
• Languages: English
• ISSNs: 2051-817X

Abstract

Abstract: Since the arterial baroreflex system is classified as an immediate control system, the focus has been on analyzing its dynamic characteristics in the frequency range between 0.01 and 1 Hz. Although the dynamic characteristics in the frequency range below 0.01 Hz are not expected to be large, actual experimental data are scant. The aim was to identify the dynamic characteristics of the carotid sinus baroreflex in the frequency range down to 0.001 Hz. The carotid sinus baroreceptor regions were isolated from the systemic circulation, and carotid sinus pressure (CSP) was changed every 10 s according to Gaussian white noise with a mean of 120 mmHg and standard deviation of 20 mmHg for 90 min in anesthetized Wistar‐Kyoto rats ( n = 8). The dynamic gain of the linear transfer function relating CSP to arterial pressure (AP) at 0.001 Hz tended to be greater than that at 0.01 Hz (1.060 ± 0.197 vs. 0.625 ± 0.067, p = 0.080), suggesting that baroreflex control was largely maintained at 0.001 Hz. Regarding nonlinear analysis, a second‐order Uryson model predicted AP with a higher R 2 value (0.645 ± 0.053) than a linear model ( R 2 = 0.543 ± 0.057, p = 0.025) or a second‐order Volterra model ( R 2 = 0.589 ± 0.055, p = 0.045) in testing data. These pieces of information may be used to create baroreflex models that can add a component of autonomic control to a cardiovascular digital twin for predicting acute hemodynamic responses to treatments and tailoring individual treatment strategies. Abstract : Although the arterial baroreflex is an important negative feedback system, its dynamic nature in the frequency range below 0.01 Hz remains to be elucidated. Despite the known resseting phenomenon to a conditioning pressure, the baroreflex maintained the dynamic gain when tested with a Gaussian white noise input with a switching interval of 10 s. These pieces of information may be used to create baroreflex models that can add a component of autonomic control to a cardiovascular digital twin for predicting acute hemodynamic responses to treatments and tailoring individual treatment strategies.