Back Cover: Amplification‐Free Detection of SARS‐CoV‐2 and Respiratory Syncytial Virus Using CRISPR Cas13a and Graphene Field‐Effect Transistors (Angew. Chem. Int. Ed. 32/2022). Issue 32 (18th July 2022)

• Record Type: Journal Article
• Authors: Li, Huijie; Yang, Jie; Wu, Guangfu; Weng, Zhengyan; Song, Yang; Zhang, Yuxuan; Vanegas, Jeffrey A.; Avery, Lori; Gao, Zan; Sun, He; Chen, Yupeng; Dieckhaus, Kevin D.; Gao, Xue; Zhang, Yi
• Is Part Of: Angewandte Chemie international edition. Volume 61:Issue 32(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-07-18
• Subjects: Amplification-Free Detection -- Biosensors -- CRISPR Cas13a -- Graphene Field-Effect Transistors -- SARS-CoV-2; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.202209501
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract : Nucleic acid detection plays a critical role in medical diagnostics, environmental monitoring, and food safety. In their Research Article (e202203826 ), Xue Gao, Yi Zhang and co‐workers developed a new biosensor for amplification‐free nucleic acid detection via harnessing the trans‐cleavage mechanism of Cas13a and ultrasensitive graphene field‐effect transistors (gFETs). The illustration shows the Cas13a‐mediated RNA trans‐cleavage on a gFET surface for sensor signal transduction.