Direct oxidation of bromo-derived Fischer–Borsche oxo-ring using molecular iodine with combined experimental and computational study. Issue 29 (18th July 2022)

• Record Type: Journal Article
• Authors: Humne, Vivek T.; Ghom, Monica H.; Naykode, Mahavir S.; Dangat, Yuvraj; Vanka, Kumar; Lokhande, Pradeep
• Is Part Of: Organic & biomolecular chemistry. Volume 20:Issue 29(2022)
• Page Start: 5726
• Page End: 5729
• Publication Date: 2022-07-18
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d2ob00793b
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A direct oxidation of the bromo-derived Fischer–Borsche oxo-ring leading to carbazolequinone using iodine has been reported. This method has been used for the synthesis of the murrayaquinone and its derivatives, with good to excellent yield. Abstract : A direct oxidation of the bromo-derived Fischer–Borsche oxo-ring leading to carbazolequinone has been developed by using molecular iodine. This unprecedented transformation has been used for the modular synthesis of the anti-cardiotonic agent murrayaquinone. Furthermore, the present method has been generalized to a broad range of functional groups, with good to excellent yield.