L-Proline, a resolution agent able to target both enantiomers of mandelic acid: an exciting case of stoichiometry controlled chiral resolution. Issue 61 (11th July 2022)

• Record Type: Journal Article
• Authors: Zhou, Fuli; Collard, Laurent; Robeyns, Koen; Leyssens, Tom; Shemchuk, Oleksii
• Is Part Of: Chemical communications. Volume 58:Issue 61(2022)
• Page Start: 8560
• Page End: 8563
• Publication Date: 2022-07-11
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d2cc02942a
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : l -Proline is used to resolve both enantiomers of mandelic acid through a stoichiometry controlled chiral resolution. Abstract : We present a thought-provoking development in chiral resolution. Using a resolving agent of a given handedness, l -proline, we show that both R- and S-enantiomers of mandelic acid can be resolved from a racemic mixture simply by varying the stoichiometry. We are the first to report this specific feature, achieved by the existence of stoichiometrically diverse cocrystal systems between R- and S-mandelic acid and l -proline.