Deep learning super-resolution magnetic resonance spectroscopic imaging of brain metabolism and mutant isocitrate dehydrogenase glioma. Issue 1 (24th May 2022)

• Record Type: Journal Article
• Authors: Li, Xianqi; Strasser, Bernhard; Neuberger, Ulf; Vollmuth, Philipp; Bendszus, Martin; Wick, Wolfgang; Dietrich, Jorg; Batchelor, Tracy T; Cahill, Daniel P; Andronesi, Ovidiu C
• Is Part Of: Neuro-oncology advances. Volume 4:Issue 1(2022)
• Publication Date: 2022-05-24
• Subjects: D-2-hydroxyglutarate -- deep learning -- glioma -- isocitrate dehydrogenase -- magnetic resonance spectroscopic imaging -- super-resolution; 616.99481
• DOI: 10.1093/noajnl/vdac071
• Languages: English
• ISSNs: 2632-2498

Abstract

Abstract: Background: Magnetic resonance spectroscopic imaging (MRSI) can be used in glioma patients to map the metabolic alterations associated with IDH1, 2 mutations that are central criteria for glioma diagnosis. The aim of this study was to achieve super-resolution (SR) MRSI using deep learning to image tumor metabolism in patients with mutant IDH glioma. Methods: We developed a deep learning method based on generative adversarial network (GAN) using Unet as generator network to upsample MRSI by a factor of 4. Neural networks were trained on simulated metabolic images from 75 glioma patients. The performance of deep neuronal networks was evaluated on MRSI data measured in 20 glioma patients and 10 healthy controls at 3T with a whole-brain 3D MRSI protocol optimized for detection of d -2-hydroxyglutarate (2HG). To further enhance structural details of metabolic maps we used prior information from high-resolution anatomical MR imaging. SR MRSI was compared to ground truth by Mann–Whitney U -test of peak signal-to-noise ratio (PSNR), structure similarity index measure (SSIM), feature-based similarity index measure (FSIM), and mean opinion score (MOS). Results: Deep learning SR improved PSNR by 17%, SSIM by 5%, FSIM by 7%, and MOS by 30% compared to conventional interpolation methods. In mutant IDH glioma patients proposed method provided the highest resolution for 2HG maps to clearly delineate tumor margins and tumor heterogeneity. Conclusions: Our results indicate that proposed deep learning methods are effective in enhancing spatial resolution of metabolite maps. Patient results suggest that this may have great clinical potential for image guided precision oncology therapy.