Visual hallucinations and inferior longitudinal fasciculus in Parkinson's disease. Issue 12 (20th October 2020)

• Record Type: Journal Article
• Authors: Yuki, Natsuko; Yoshioka, Akira; Mizuhara, Ryo; Kimura, Tadashi
• Is Part Of: Brain and behavior. Volume 10:Issue 12(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-10-20
• Subjects: diffusion tensor imaging -- inferior longitudinal fasciculus -- Parkinson's disease -- visual hallucination -- white matter; Neurology -- Periodicals; Neurosciences -- Periodicals; Psychology -- Periodicals; Psychiatry -- Periodicals; 616.8005
• DOI: 10.1002/brb3.1883
• Languages: English
• ISSNs: 2162-3279

Abstract

Abstract: Introduction: We investigated whether disruption of the inferior longitudinal fasciculus and inferior fronto‐occipital fasciculus are associated with visual hallucinations in Parkinson's disease (PD). Methods: Sixty consecutive right‐handed patients with PD with and without visual hallucinations were enrolled in this cross‐sectional study. Diffusion tensor imaging was acquired by 3.0 T magnetic resonance imaging. We measured fractional anisotropy and mean diffusivity of the bilateral inferior longitudinal fasciculus and inferior fronto‐occipital fasciculus using diffusion tensor tractography analysis software. Results: Seventeen patients with PD had visual hallucinations; these patients tended to have lower fractional anisotropy and higher mean diffusivity values in all fasciculi than did patients without visual hallucinations. A univariate logistic analysis showed that the presence of visual hallucinations was significantly associated with lower fractional anisotropy and higher mean diffusivity of the left inferior longitudinal fasciculus, and lower Mini‐Mental State Examination (MMSE) scores. A multivariable logistic analysis adjusted by MMSE scores and disease duration showed a significant association between the presence of visual hallucinations and fractional anisotropy and mean diffusivity values of the left inferior longitudinal fasciculus. Conclusions: Our results suggest that disruption of left inferior longitudinal fasciculus integrity is associated with visual hallucinations in patients with PD, independent of cognitive impairment and disease duration. Abstract : We investigated whether disruption of the inferior longitudinal fasciculus is associated with visual hallucinations in Parkinson's disease (PD) used by diffusion tensor imaging. A multivariable logistic analysis adjusted by MMSE scores showed a significant association between the presence of visual hallucinations and fractional anisotropy and mean diffusivity values of the left inferior longitudinal fasciculus. Our results suggest that disruption of left inferior longitudinal fasciculus integrity is associated with visual hallucinations in patients with PD, independent of cognitive impairment.