The molecular regulation of autophagy in antimicrobial immunity. (12th March 2022)

• Record Type: Journal Article
• Authors: Qin, Chuan; Lu, Yalan; Bai, Lin; Wang, Kewei
• Editors: Su, Bing
• Is Part Of: Journal of molecular cell biology. Volume 14:Number 4(2022)
• Publication Date: 2022-03-12
• Subjects: autophagy -- microbe -- antimicrobial immunity -- endoplasmic reticulum stress -- unfolded protein response -- apoptosis -- infectious disease; Molecular biology -- Periodicals; 571.605
• DOI: 10.1093/jmcb/mjac015
• Languages: English
• ISSNs: 1674-2788

Abstract

Abstract: Autophagy is a catabolic process that can degrade worn-out organelles and invading pathogens. The activation of autophagy regulates innate and adaptive immunity, playing a key role in the response to microbial invasion. Microbial infection may cause different consequences such as the elimination of invaders through autophagy or xenophagy, host cell death, and symbiotic relationships. Pathogens adapt to the autophagy mechanism and further relieve intracellular stress, which is conducive to host cell survival and microbial growth. The regulation of autophagy forms a complex network through which host immunity is modulated, resulting in a variety of pathophysiological manifestations. Modification of the autophagic pathway is an essential target for the development of antimicrobial drugs.