Effects of aging on basement membrane of tibialis anterior muscle during recovery following muscle injury in rats. (29th March 2022)

• Record Type: Journal Article
• Authors: Kanazawa, Yuji; Nagano, Mamoru; Koinuma, Satoshi; Sugiyo, Shinichi; Shigeyoshi, Yasufumi
• Is Part Of: Microscopy. Volume 71:Number 4(2022)
• Page Start: 245
• Page End: 248
• Publication Date: 2022-03-29
• Subjects: muscle injury -- aging -- basement membrane -- skeletal muscle -- collagen IV -- recovery; Microscopy -- Periodicals; 502.825
• DOI: 10.1093/jmicro/dfac016
• Languages: English
• ISSNs: 2050-5698

Abstract

Abstract: We investigated the effect of aging on the basement membrane (BM) during postinjury muscle recovery. Using a rat model, we found that aging delayed muscle fiber and BM recovery. In addition, expression of BM-related factors peaked 7 days after muscle injury among both young and older rats. Peak expression of collagen IV synthetic factors decreased with age, whereas expression of the degradative factor was unaffected by age. These results suggest that age-related delays in postinjury muscle fiber and BM recovery may be related to the suppression of collagen IV synthetic factors.