Low-Dose NSAIDs Efficacy in Orthopedic Applications. Issue 3 (3rd September 2022)

• Record Type: Journal Article
• Authors: Oliva, Francesco; Quaranta, Marco; Cipollaro, Lucio; Conti, Valeria; De Bellis, Emanuela; Filippelli, Amelia; Maffulli, Nicola
• Is Part Of: Sports medicine and arthroscopy review. Volume 30:Issue 3(2022)
• Page Start: 147
• Page End: 161
• Publication Date: 2022-09-03
• Subjects: low-dose NSAIDs orthopedic -- low-dose NSAIDs diclofenac orthopedic -- low-dose diclofenac arthritis -- low-dose NSAIDs in lumbar pain; Sports medicine -- Periodicals; Arthroscopy -- Periodicals; 617.1027
• DOI: 10.1097/JSA.0000000000000353
• Languages: English
• ISSNs: 1062-8592

Abstract

Abstract : Non-steroidal anti-inflammatory drugs (NSAIDs) [cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) inhibitors] and COXIBs (the COX-2 selective inhibitors) may induce several potentially severe and life-threatening issues especially in elderly patients. The use of low-dose NSAIDs is associated with lower risk of side effects compared to the standard dosage. Low-dose NSAIDs could minimize the side effects of these drugs while maintaining their clinical efficacy and effectiveness. The present study evaluates the effectiveness and safety of low-dose NSAIDs in musculoskeletal applications.