A Dual-Coreactants Electrochemiluminescent Immunosensor for Procalcitonin Detection Based on CdS-MoS2 Nanocomposites. Issue 5 (1st January 2018)

• Record Type: Journal Article
• Authors: Chen, Peipei; Xia, Fangquan; Tian, Dong; Zhou, Changli
• Is Part Of: Journal of the Electrochemical Society. Volume 165:Issue 5(2018)
• Page Start: B196
• Page End: B201
• Publication Date: 2018-01-01
• Subjects: CdS-MoS2 nanocomposites -- dual-coreactants -- procalcitonin; Electrochemistry -- Periodicals; 541.3705
• DOI: 10.1149/2.0531805jes
• Languages: English
• ISSNs: 0013-4651

Abstract

Abstract : A novel dual-coreactants electrochemiluminescent (ECL) immunosensor based on CdS-MoS2 nanocomposites was designed for detection of procalcitonin (PCT). The CdS-MoS2 nanocomposites were synthesized through a simple one-pot hydrothermal method, and served as highly efficient luminescent material for the ECL immunosensor. In addition, we used H2 O2 and K2 S2 O8 as dual-coreactants, generating stronger ECL emission than that of K2 S2 O8 or H2 O2 as an individual coreactant, which could improve sensitivity of the immunosensor. Under optimum conditions, the ECL assay for PCT detection was developed with excellent sensitivity of a concentration variation from 0.0001 to 10 ng mL −1 and limit of detection down to 33 fg mL −1 (RSD = 0.10). Additionally, the proposed immunosensor showed high specificity, good reproducibility, and long-term stability.