Polymorphisms rs763110 in FASL is linked to hepatitis C virus infection among high-risk populations. Issue 3 (2nd July 2020)

• Record Type: Journal Article
• Authors: Huang, P; Wang, CH; Zhuo, LY; Xia, XS; Yang, S; Zhang, JW; Fan, HZ; Wu, JJ; Yu, R; Yue, M; Zhang, Y
• Is Part Of: British journal of biomedical science. Volume 77:Issue 3(2020)
• Page Start: 112
• Page End: 117
• Publication Date: 2020-07-02
• Subjects: Hepatitis C Virus -- fas receptor -- fas ligand -- decoy receptor 3 -- single nucleotide polymorphisms; Medical sciences -- Periodicals; Medical technology -- Periodicals; Biological Science Disciplines; Clinical Laboratory Techniques; Medical Laboratory Science; Anatomie pathologique; Medical sciences; Medical technology; Klinische chemie; Laboratoriumonderzoek; Periodicals; Periodicals; 616.0756; 610.07 M489L
• DOI: 10.1080/09674845.2020.1747182
• Languages: English
• ISSNs: 0967-4845

Abstract

ABSTRACT: Background: The Fas cell surface death receptor (FAS) and Fas ligand (FASL) can participate in the apoptosis of immune cells and target cells infected with a virus through the FAS-FASL signalling pathway. The decoy receptor 3 (DCR3) can competitively inhibit the binding of FAS to FASL. Our aim is to investigate the effect of single nucleotide polymorphisms (SNPs) in FAS, FASL and DCR3 on hepatitis C virus (HCV) infection. Methods: Four SNPs (rs763110 in FASL, rs1324551 and rs2234767 in FAS and rs2257440 in DCR3 ) were genotyped in 1495 controls free of HCV, 522 individuals with spontaneous HCV clearance and 732 patients with hepatitis C virus infection. The RegulomeDB database and RNAfold web servers were used to explore potential biological functions of SNPs. Results: FASL rs763110 was associated with susceptibility to HCV infection, and not to CHC. The odds ratio (95% confidence interval) of HCV infection in high-risk populations carrying FASL rs763110-TT was 1.82 (1.36–2.51, P < 0.001) compared to that of CC genotypes and 1.93 (1.43–2.60, P < 0.001) higher than that of CC + CT genotypes. Based on computer simulation, FASL rs763110-T may affect the transcription of mRNA by affecting the binding of a transcription factor, leading to structural changes in mRNA. Conclusion: The genetic variant in FASL is linked with HCV infection, but not to spontaneous HCV clearance.