N-terminal [Glu]3 moiety of γ-glutamyl peptides contributes largely to the activation of human calcium-sensing receptor, a kokumi receptor. Issue 7 (2nd July 2020)

• Record Type: Journal Article
• Authors: Yamamoto, Mizuki; Terada, Yuko; Motoyama, Takayasu; Shibata, Munehisa; Saito, Tsutomu; Ito, Keisuke
• Is Part Of: Bioscience, biotechnology, and biochemistry. Volume 84:Issue 7(2020)
• Page Start: 1497
• Page End: 1500
• Publication Date: 2020-07-02
• Subjects: gamma-glutamyl peptide -- calcium-sensing receptor -- structure-activity relationship study -- kokumi; Biotechnology -- Periodicals; Biochemistry -- Periodicals; 660.6
• DOI: 10.1080/09168451.2020.1743169
• Languages: English
• ISSNs: 0916-8451

Abstract

ABSTRACT: γ-glutamyl peptides have been suggested to impart kokumi properties to foods by activating human calcium-sensing receptor (hCaSR). In this study, the relationship between γ-glutamyl peptide structure and hCaSR activity was systematically analyzed using γ-[Glu](n=0-4) -α-[Glu](n=0-3) -Tyr. Our results suggest that N-terminal [Glu]3 moiety is very important for hCaSR activities of γ-glutamyl peptides.