New phenylspirodrimane metabolites MBJ-0030, MBJ-0031, and MBJ-0032 isolated from the soil fungal strain Stachybotrys sp. f23793. Issue 8 (2nd August 2020)

• Record Type: Journal Article
• Authors: Kawahara, Teppei; Itoh, Masashi; Izumikawa, Miho; Kagaya, Noritaka; Sakata, Noriaki; Tsuchida, Toshio; Shin-ya, Kazuo
• Is Part Of: Bioscience, biotechnology, and biochemistry. Volume 84:Issue 8(2020)
• Page Start: 1570
• Page End: 1575
• Publication Date: 2020-08-02
• Subjects: Stachybotrys -- stachybotrin -- phenylspirodrimane; Biotechnology -- Periodicals; Biochemistry -- Periodicals; 660.6
• DOI: 10.1080/09168451.2020.1757402
• Languages: English
• ISSNs: 0916-8451

Abstract

ABSTRACT: Chemical screening of culture medium from the soil fungus Stachybotrys sp. resulted in the isolation of the three new phenylspirodrimanes MBJ-0030 (1 ), MBJ-0031 (2 ) and MBJ-0032 (3 ). Their structures were determined by detailed analysis of spectroscopic data. The absolute configurations of 1 –3 were determined by modified Mosher's and Marfey's methods. In addition, cytotoxic and antimicrobial evaluations of the compounds were conducted. GRAPHICAL ABSTRACT: uf0001 The structure of new phenylspirodrimane metabolites MBJ-0030, MBJ-0031, and MBJ-0032 isolated from the soil fungal strain Stachybotrys sp. f23793.