P1421: BIMODAL TARGETING OF CYTOKINE RECEPTOR-LIKE FACTOR 2 (CRLF2) WITH JAK INHIBITION AND CHIMERIC ANTIGEN RECEPTOR T CELL IMMUNOTHERAPY IN DOWN SYNDROME ACUTE LYMPHOBLASTIC LEUKEMIA. (23rd June 2022) - Bagashev, A.; Loftus, J.; Niswander, L.; Ross, S.; Falkenstein, C. D.; Junco, J.; Rabin, K. R.; Fry, T.; Tasian, S. K.