Serum long noncoding RNAs FAS-AS1 & PVT1 are novel biomarkers for systemic lupus erythematous. Issue 4 (1st October 2020)

• Record Type: Journal Article
• Authors: Ali, MA; Shaker, OG; Khalefa, AA; Abdelwahed, MY; Ali, EGI; Ezzat, EM; Elghobary, HA; Awaji, AA; Fouad, NA; Ayoub, SE
• Is Part Of: British journal of biomedical science. Volume 77:Issue 4(2020)
• Page Start: 208
• Page End: 212
• Publication Date: 2020-10-01
• Subjects: FAS-AS1; PVT1; qRT-PCR -- Systemic Lupus Erythematous -- SLE; Medical sciences -- Periodicals; Medical technology -- Periodicals; Biological Science Disciplines; Clinical Laboratory Techniques; Medical Laboratory Science; Anatomie pathologique; Medical sciences; Medical technology; Klinische chemie; Laboratoriumonderzoek; Periodicals; Periodicals; 616.0756; 610.07 M489L
• DOI: 10.1080/09674845.2020.1765459
• Languages: English
• ISSNs: 0967-4845

Abstract

ABSTRACT: Background : Systemic Lupus Erythematous (SLE) is a chronic systemic autoimmune disorder whose diagnosis depends on combination of multiple factors. Circulating lncRNAs could serve as diagnostic non-invasive biomarkers for SLE. We hypothesised that serum FAS-AS1 and PVT1 are new biomarkers for SLE that relate to clinical features and laboratory markers. Materials and Method : Measurement of serum FAS-AS1 & PVT1 by qRT-PCR, analysis of the association between two RNAs and the clinical data, activity index and laboratory markers by standard routine methods. Results : There was a significant relative increased serum FAS-AS1 (median (IQR) 2.19 (0.13–8.62) and a significant reduced PVT1 (median (IQR) 0.52 (0.01–7.55) in SLE patients compared to controls ( P < 0.0001 for FAS-AS1 and = 0.007 for PVT1). Serum FAS-AS1 and PVT1 were positively correlated ( r = 0.37, P = 0.001). Higher FAS-AS1 was significantly linked with nephritis ( P = 0.011), positive anti-dsDNA ( P = 0.01) and lower serum PVT1 was significantly associated with oral ulcers ( P = 0.023), photosensitivity ( P = 0.017), and neurological manifestations ( P = 0.041). Serum PVT1 negatively correlated with age ( r = −0.52, P < 0.0001) and ESR level ( r = −0.29, P = 0.011) in SLE patients. No correlation between disease activity and serum FAS-AS1 or PVT1 was detected. Conclusions : Our study provides evidence that serum FAS-AS1 and PVT1 are new biomarkers for SLE.