Relevance of KISS1 gene polymorphisms in susceptibility to polycystic ovary syndrome and its associated endocrine and metabolic disturbances. Issue 4 (1st October 2020)

• Record Type: Journal Article
• Authors: Daghestani, MH; Daghestani, MH; Daghistani, M; Ambreen, K; Almuammar, MN; Al Neghery, LM; Warsy, AS
• Is Part Of: British journal of biomedical science. Volume 77:Issue 4(2020)
• Page Start: 185
• Page End: 190
• Publication Date: 2020-10-01
• Subjects: polycystic ovary syndrome -- KISS1 gene polymorphisms -- metabolic and endocrine disturbances -- insulin hypersecretion -- LH -- oestradiol; Medical sciences -- Periodicals; Medical technology -- Periodicals; Biological Science Disciplines; Clinical Laboratory Techniques; Medical Laboratory Science; Anatomie pathologique; Medical sciences; Medical technology; Klinische chemie; Laboratoriumonderzoek; Periodicals; Periodicals; 616.0756; 610.07 M489L
• DOI: 10.1080/09674845.2020.1726662
• Languages: English
• ISSNs: 0967-4845

Abstract

ABSTRACT: Background : Variations in KISS1 may be an emerging factor in polycystic ovary syndrome (PCOS) We hypothesised links between KISS1 polymorphisms in PCOS and its associated endocrine and metabolic disturbances. Methods : The study included 104 PCOS women and 109 controls. Endocrine (kisspeptin, LH, FSH, LH-FSH ratio, oestradiol) and metabolic (cholesterol, triglycerides, HDL, LDL, insulin and glucose) parameters were measured. PCR and nucleotide sequencing were carried out to screen single nucleotide polymorphisms (SNPs) of KISS1 . Endocrine and metabolic parameters of PCOS women were compared in the genotypes. Results : Three novel SNPs (rs1213704663C>G, rs1481572212T>G and rs775770652G>A) were detected in KISS1 . Of these SNPs, the genotype and allele frequencies of rs1213704663C>G were all significantly associated p<0.001 with PCOS. The LH and oestradiol hypersecretion, and increased LH-FSH ratio of PCOS women were significantly influenced by the GG genotype of rs1213704663, but, this SNP did not influence kisspeptin levels. The other two SNPs rs1481572212T>G and rs775770652G>A exhibited no clinical significance. Conclusion : rs1213704663C>G variation in KISS1 is linked to PCOS and its associated endocrine and metabolic disturbances (LH and oestradiol hypersecretion, and increased LH/FSH).