Invasive mucinous adenocarcinoma of the lung arising in a type 1 congenital pulmonary airway malformation in a 68-year-old patient: a case report. Issue 1 (2nd January 2021)

• Record Type: Journal Article
• Authors: Frick, A. E.; Decaluwé, H.; Weynand, B.; Proesmans, M.; Van Raemdonck, D.
• Is Part Of: Acta chirurgica belgica. Volume 121:Issue 1(2021)
• Page Start: 55
• Page End: 60
• Publication Date: 2021-01-02
• Subjects: Congenital pulmonary air malformation -- invasive mucinous adenocarcinoma -- epidermal growth factor; Surgery -- Periodicals; General Surgery; Chirurgie -- Périodiques; Surgery; Chirurgie (geneeskunde); Periodicals; Periodicals; 617.005
• DOI: 10.1080/00015458.2019.1634926
• Languages: English
• ISSNs: 0001-5458

Abstract

Abstract: Introduction: Congenital pulmonary airway malformation (CPAM), previously described as congenital cystic adenomatoid malformation (CCAM), is a congenital disorder of lung parenchyma. The association with the presence of a malignant transformation like rhabdomyosarcoma, pleuropulmonary blastoma, and most common invasive mucinous adenocarcinoma (IMA) is a rare development described in patients with CPAM. Patients and methods: Here, we report the case of a 68-year-old male patient who underwent a right lower lobectomy for a mass in the right pulmonary lobe. From his clinical history, we noted a recurrent pulmonary infection of a bullous malformation in the right lower lobe treated with antibiotics. Results: The histopathological finding showed an invasive mucinous adenocarcinoma arising in a type 1 CPAM in the right lower lobe. A review of presentation, diagnosis, and treatment of this association is described in a case report. Conclusions: Surgical resection should be considered in adults with asymptomatic cysts to prevent malignant transformation. For further analysis, histopathological examination of specimen is essential for a proper diagnosis and eventually further postoperative treatment.