A cloud-based platform for the non-invasive management of coronary artery disease. Issue 8 (13th September 2020)

• Record Type: Journal Article
• Authors: Sakellarios, Antonis; Correia, Joao; Kyriakidis, Savvas; Georga, Elena; Tachos, Nikolaos; Siogkas, Panagiotis; Sans, Francisco; Stofella, Paolo; Massimiliano, Valiani; Clemente, Alberto; Rocchiccioli, Silvia; Pelosi, Gualtiero; Filipovic, Nenad; Fotiadis, Dimitrios I.
• Is Part Of: Enterprise information systems. Volume 14:Issue 8(2020)
• Page Start: 1102
• Page End: 1123
• Publication Date: 2020-09-13
• Subjects: Cardiovascular disease -- cloud-platform -- CDSS -- cyber-physical systems -- interoperability; Information storage and retrieval systems -- Periodicals; Management information systems -- Periodicals; Electronic commerce -- Periodicals; 658.4038011
• DOI: 10.1080/17517575.2020.1746975
• Languages: English
• ISSNs: 1751-7575

Abstract

ABSTRACT: We present the architecture and the usability testing of a novel cloud-based platform, which integrates cyber-physical systems and interoperability standards enabling a clinical decision support system for risk stratification, diagnosis, prognosis and treatment of CAD. In this work multi-disciplinary human data were used for the development of machine learning and computational biomechanics based predictive models. Two Lab-on-Chip devices have been integrated into the cloud platform. A targeted RNA-panel provides the mRNA gene expression values for the stratification algorithm. The results of the usability testing demonstrate that the platform is efficient, accurate and performs all developed tasks quickly.