Acute effects of lactic acid-fermented and enzyme-digested soybean on protein synthesis via mTOR signaling in the skeletal muscle. Issue 11 (1st November 2020)

• Record Type: Journal Article
• Authors: Ono, Kohei; Tanaka, Minoru; Ikeji, Takuya; Nakanishi, Ryosuke; Hirabayashi, Takumi; Tategaki, Airo; Kondo, Hiroyo; Ishihara, Akihiko; Fujino, Hidemi
• Is Part Of: Bioscience, biotechnology, and biochemistry. Volume 84:Issue 11(2020)
• Page Start: 2360
• Page End: 2366
• Publication Date: 2020-11-01
• Subjects: Soybean -- lactic acid-fermented and enzyme-digested soybean -- muscle protein synthesis -- mTOR pathway -- ribosomal protein S6; Biotechnology -- Periodicals; Biochemistry -- Periodicals; 660.6
• DOI: 10.1080/09168451.2020.1795810
• Languages: English
• ISSNs: 0916-8451

Abstract

ABSTRACT: Protein-containing nutrients result in the efficient hypertrophy of muscles by increasing muscle protein synthesis. Soybean is often ingested by athletes or individuals who exercise; however, it takes very long to be absorbed. Lactic acid-fermented and enzyme-digested (LFED) soybean is absorbed faster than untreated soybean. This study aims at determining muscle protein synthesis after ingesting a single bolus of soybean or LFED soybean produced by lactic acid bacteria and protease digestion. Eight-week-old overnight-fasted ICR mice were administered powdered or LFED soybean. Mice were euthanized at 7, 15, 30, 60, 90, and 120 min after soybean intake. We have demonstrated that LFED soybean administration was quicker in stimulating muscle protein synthesis by activating mammalian target of rapamycin (mTOR) signaling than orally ingesting untreated soybean in the gastrocnemius muscle. These results suggested that LFED soybean is a more efficient source of nutrition for muscle hypertrophy than untreated soybean. GRAPHIC ABSTRACT: uf0001 Schema for acute effects of lactic acid-fermented and enzyme-digested soybean on protein synthesis via mTOR signaling in the skeletal muscle