Use of fomepizole as an adjunct in the treatment of acetaminophen overdose: a case series. Issue 1 (1st January 2020)

• Record Type: Journal Article
• Authors: Rampon, Garrett; Wartman, Haley; Osmon, Stephen; Scalzo, Anthony
• Is Part Of: Toxicology communications. Volume 4:Issue 1(2020)
• Page Start: 1
• Page End: 4
• Publication Date: 2020-01-01
• Subjects: Acetaminophen -- fomepizole -- overdose -- hepatotoxicity -- acute liver failure; Toxicology -- Periodicals; 615.9005
• DOI: 10.1080/24734306.2019.1705596
• Languages: English
• ISSNs: 2473-4306

Abstract

Abstract: Acetaminophen toxicity remains a leading cause of acute liver failure in the United States and world-wide. Fomepizole is a cytochrome P450 inhibitor that may inhibit production of toxic metabolites of acetaminophen. However there are limited clinical data of its use for this purpose in the literature. Here we present a case series of six patients treated with fomepizole for acute acetaminophen toxicity who sustained no substantial liver injury.