S-Benzyl-N, N'-diphenyl substituted isothiouronium iodide as a highly efficient organocatalyst for transfer hydrogenation of 2-substituted quinolines. (9th November 2021)

• Record Type: Journal Article
• Authors: Kang, Sungmin; Kim, Taek Hyeon
• Is Part Of: Tetrahedron letters. Volume 84(2021)
• Publication Date: 2021-11-09
• Subjects: S-Benzyl-N, N'-diphenyl isothiouronium iodide -- Transfer hydrogenation -- 2-Substituted quinolines -- Hantzsch ester; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2021.153450
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Abstract: An isothiouronium organocatalyst prepared from thiourea was first employed to catalyze the transfer hydrogenation of various 2-alkyl and arylquinolines with Hantzsch ester as the hydrogen source. This metal-free catalyzed reduction of 2-substituted quinoline efficiently rendered good to excellent yields of tetrahydroquinolines under mild conditions with a small amount of catalyst (5 mol%).