Postpartum depression biomarkers predict exacerbation of OCD symptoms during pregnancy. (November 2020)

• Record Type: Journal Article
• Authors: Kaminsky, Zachary A.; Osborne, Lauren M.; Guglielmi, Valeria; Jones, Ilenna; Grenier, Winston; Clark, Karen; Ross, Evelyn; Meilman, Samantha; Nestadt, Paul; Payne, Jennifer L.; Samuels, Jack; Nestadt, Gerald
• Is Part Of: Psychiatry research. Volume 293(2020)
• Publication Date: 2020-11
• Subjects: Obsessive compulsive disorder -- pregnancy -- postpartum depression -- biomarkers -- epigenetics -- TTC9B -- HP1BP3; Psychiatry -- Periodicals; Psychiatry -- periodicals; Psychiatrie -- Périodiques; 616.89
• DOI: 10.1016/j.psychres.2020.113332
• Languages: English
• ISSNs: 0165-1781

Abstract

Highlights: Epigenetic biomarkers of postpartum depression, HP1BP3 and TTC9B, predict exacerbation of OCD symptoms during pregnancy. A methylome wide approach identifies MS4A7 as a DNA methylation proxy of the ratio of monocytes to non-monocytes. Incorporation of MS4A7 into the prediction model improves OCD symptom exacerbation prediction to 75%.