Association between the ACE I/D polymorphism and muscle injuries in Italian and Japanese elite football players. Issue 21 (1st November 2020)

• Record Type: Journal Article
• Authors: Massidda, Myosotis; Miyamoto-Mikami, Eri; Kumagai, Hiroshi; Ikeda, Hayato; Shimasaki, Yu; Yoshimura, Masafumi; Cugia, Paolo; Piras, Francesco; Scorcu, Marco; Kikuchi, Naoki; Calò, Carla Maria; Fuku, Noriyuki
• Is Part Of: Journal of sports sciences. Volume 38:Issue 21(2020)
• Page Start: 2423
• Page End: 2429
• Publication Date: 2020-11-01
• Subjects: Angiotensin-converting enzyme -- gene -- muscle disorders -- polymorphism -- soccer; Sports -- Periodicals; Sports -- Physiological aspects -- Periodicals; Sports -- Psychological aspects -- Periodicals; 612.044
• DOI: 10.1080/02640414.2020.1787683
• Languages: English
• ISSNs: 0264-0414

Abstract

ABSTRACT: ACE I/D polymorphism has been recently associated with the susceptibility to inflammation and muscle damage after exercise. The aim of this study was to understand the association between the ACE I/D polymorphism and muscle injuries in a large cohort of elite football players from two different countries. Seven hundred and ten male elite football players from Italy (n = 341) and Japan (n = 369) were recruited for the study. Genomic DNA was extracted from either the buccal epithelium or saliva using a standard protocol. Structural-mechanical injuries and functional muscle disorders were recorded from 2009 to 2018. A meta-analysis was performed using Review Manager 5.3.5. In the Japanese cohort, the ACE I/D polymorphism was significantly associated with muscle injury using the D-dominant model (OR: 0.48, 95% CI: 0.24–0.97, P = 0.040). The meta-analysis showed that in the pooled model (Italian and Japanese populations), the frequencies of the DD+ID genotypes were significantly lower in the injured groups than in non-injured groups (OR: 0.61, 95% CI: 0.38–0.98, P = 0.04) with a low degree of heterogeneity ( I 2 = 0%). Our findings suggest that the ACE I/D polymorphism could influence the susceptibility to developing muscle injuries among football players.