Strain Echocardiography in Early Detection of Doxorubicin-Induced Left Ventricular Dysfunction in Children with Acute Lymphoblastic Leukemia. (24th January 2012)

• Record Type: Journal Article
• Authors: Al-Biltagi, Mohammed; Abd Rab Elrasoul Tolba, Osama; El-Shanshory, Mohammed Ramadan; Abd El-Aziz El-Shitany, Nagla; El-Sayed El-Hawary, Eslam
• Other Names: Anderson M. S. Academic Editor.; Siberry G. Academic Editor.
• Is Part Of: ISRN pediatrics. Volume 2012(2012)
• Publication Date: 2012-01-24
• Subjects: Pediatrics -- Periodicals; Pediatrics; Pediatrics; Periodicals; 618.92
• DOI: 10.5402/2012/870549
• Languages: English
• ISSNs: 2090-469X

Abstract

Abstract : Objective . To investigate the ability of two-dimensional longitudinal strain echocardiography (2DST), to detect the early doxorubicin cardiotoxicity. Patients and Methods . The study included 25 children with newly diagnosed acute lymphoblastic leukemia (ALL) aged 5–15 years and 30 healthy control children. They had echocardiographic examination with conventional 2-dimensional (2D), pulsed tissue Doppler (PTD), and 2DST echocardiography before and within 1 week after doxorubicin treatment. Results . There was no significant difference in left ventricle (LV) systolic and diastolic functions measured by conventional 2-D and PTD echocardiography between patients and controls. However, there was significant decrease in LV global and peak systolic strain detected by 2-DST echocardiography in study group than control. After doxorubicin treatment, there was no significant difference in LV systolic and diastolic functions measured by conventional 2-D and PTD echocardiography than before treatment except for prolonged IVCT and IVRT, but LV global and peak systolic strain was significantly lower after treatment. Conclusion . 2-D longitudinal strain echocardiography was more sensitive than conventional 2-D and PTD in detecting the early LV doxorubicin-induced cardiotoxicity in children with ALL.