Antimicrobial, anti-cancer, anti-filarial and anti-inflammatory activities of Cowabenzophenone A extracted from the endophytic fungus Aspergillus terreus isolated from a mangrove plant Bruguiera gymnorrhyza. Issue 4 (1st October 2020)

• Record Type: Journal Article
• Authors: Ukwatta, Kushan M.; Lawrence, Jennifer L.; Wijayarathne, C. D.
• Is Part Of: Mycology. Volume 11:Issue 4(2020)
• Page Start: 297
• Page End: 305
• Publication Date: 2020-10-01
• Subjects: Cowabenzophenone A -- Aspergillus terreus -- Bruguiera gymnorrhyza -- endophytic fungus -- anti-inflammatory; Fungi -- Periodicals; Mycology -- Periodicals; Fungi; Mycology; Periodicals; 579.505
• DOI: 10.1080/21501203.2019.1707722
• Languages: English
• ISSNs: 2150-1203

Abstract

ABSTRACT: Cowabenzophenone A was isolated from an endophytic fungus Aspergillus terreus isolated from a mangrove plant Bruguiera gymnorrhyza. The structure was determined by analysis of 1D and 2D NMR spectra and mass spectrometric data as a tetracyclo[7.3.3.33, 11.03, 7]tetradecane-2, 12, 14-trione skeleton. When the compound was tested in vitro for its ability to inhibit inflammations, α-glucosidase inhibitory activities and its antimicrobial properties, it showed an anti-inflammatory activity amounting to an IC50 of 12.1 µg/mL, α-glucosidase inhibitory activity, with IC50 values of 7.8 ± 0.5 μM, and antibacterial activity against Bacillus subtilis TISTR 088, and Bacillus cereus TISTR 688 with MIC values of 1 μg/mL and 2 μg/mL respectively. The compound showed cytotoxicity against HCT 116 colon cancer cell line with an IC50 value of 10.1 ?M, and also showed a considerably high potential towards anti-filarial activities by resulting MIC, IC50 and LC50 values of 0.358 ± 0.02 mg/mL, 0.708 ± 0.021 mg/mL and 3.89 ± 0.18 mg/mL, respectively, in comparison to the standard drug Ivermectin (IVM).