Could threshold cycle value correctly reflect the severity of novel coronavirus disease 2019 (COVID-19)?. Issue 1 (January 2021)

• Record Type: Journal Article
• Authors: Asai, Nobuhiro; Sakanashi, Daisuke; Ohashi, Wataru; Nakamura, Akiko; Yamada, Atsuko; Kawamoto, Yuzuka; Miyazaki, Narimi; Ohno, Tomoko; Koita, Isao; Suematsu, Hiroyuki; Kishino, Takaaki; Kato, Hideo; Hagihara, Mao; Shiota, Arufumi; Koizumi, Yusuke; Yamagishi, Yuka; Mikamo, Hiroshige
• Is Part Of: Journal of infection and chemotherapy. Volume 27:Issue 1(2021)
• Page Start: 117
• Page End: 119
• Publication Date: 2021-01
• Subjects: COVID-19 -- SARS-CoV-2 -- RT-PCR -- Coronavirus -- Wuhan; Chemotherapy -- Periodicals; Infection -- Periodicals; Communicable diseases -- Chemotherapy -- Periodicals; 615.5805
• DOI: 10.1016/j.jiac.2020.09.010
• Languages: English
• ISSNs: 1341-321X

Abstract

Abstract: The novel coronavirus disease 2019 (COVID-19) is diagnosed by positive result of reverse transcription polymerase chain reaction (RT-PCR) for the novel coronavirus. We concluded that cycle threshold value (Ct-value) of real-time RT-PCR (rRT-PCR) assay could decrease as patients recover. Results of rRT-PCR assay could remain positive among asymptomatic patients for longer than 2 weeks. The discharge criteria of COVID-19 patients using a negative result of rRT-PCR should be reconsidered.