Urinary apolipoprotein M as a biomarker of acute kidney injury in children undergoing heart surgery. (January 2016)

• Record Type: Journal Article
• Authors: Madsen Svarrer, Eva Martha; Andersen, Henrik Ørbæk; Helvind, Morten; Slagman, Maartje CJ; Navis, Gerjan; Dullaart, Robin PF; Dahlbäck, Björn; Nielsen, Lars Bo
• Is Part Of: Biomarkers in medicine. Volume 10:Number 1(2016)
• Page Start: 81
• Page End: 93
• Publication Date: 2016-01
• Subjects: acute kidney injury -- AKI -- apoM -- Apolipoprotein M -- biomarker -- cardiac surgery -- urine; Biochemical markers -- Periodicals; 610.28
• DOI: 10.2217/bmm.15.105
• Languages: English
• ISSNs: 1752-0363

Abstract

Aim: To investigate whether apoM is excreted in urine of children undergoing heart surgery and the potential of apoM as early biomarker of acute kidney injury (AKI).Materials & methods: Urine was collected in children undergoing heart surgery. ApoM was measured with ELISA. U-apoM was characterized by gel filtration chromatography and western blotting.Results: ApoM was excreted into the urine 0–4 h postoperatively as the full-length apoM in particles smaller than plasma HDL. At 0 h, U-apoM predicted AKI with an area under the receiver-operating characteristics curve of 0.70 (p < 0.018). Sensitivity was 0.71 and specificity was 0.68 at a cutoff level at 1.45 nmol/l.Conclusion: ApoM is excreted in the urine of children after cardiac surgery. Its potential as biomarker of AKI deserves exploration.