Organic fluorescent nanoparticles with NIR-II emission for bioimaging and therapy. (22nd January 2021)

• Record Type: Journal Article
• Authors: Dang, Huiping; Yan, Lifeng
• Is Part Of: Biomedical materials. Volume 16:Number 2(2021)
• Publication Date: 2021-01-22
• Subjects: NIR-II fluorescence imaging -- photothermal therapy -- tail emission -- brightness; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1088/1748-605X/abca4a
• Languages: English
• ISSNs: 1748-6041

Abstract

Abstract: Fluorescence imaging technology in the second near-infrared bio-channel (NIR-II) has the advantages of low light scattering and weak autofluorescence. It can obtain high spatial resolution imaging in deeper biological tissues and realize accurate diagnosis in the lesion. As a new cancer treatment method, photothermal therapy has the characteristics of obvious curative effect and small side effects. However, the hydrophobicity and non-selectivity of many fluorescent materials, aggregation-induced fluorescence quenching, and other problems lead to undesirable imaging results. Here, we reviewed the structure of the NIR-II fluorescent molecules and these dyes whose fluorescence tail emission is in the NIR-II bio-channel, discussed in detail how to realize the redshift of the dye wavelength, including modifying the push–pull electron system, extending the conjugated chain, and forming J-aggregates and other methods. We also summarize some strategies to improve brightness, including responsiveness, targeting, adjustment of aggregation mode, and aggregation-induced emission effect, thereby improving the imaging performance and therapeutic effect of NIR-II fluorescent dyes.