Chemo- and stereoselective synthesis of E-2-(2-acyl-1-tosylvinyl)pyrroles from tosylmethyl isocyanide (TosMIC) and 2-(acylethynyl)pyrroles. (9th November 2021)

• Record Type: Journal Article
• Authors: Saliy, Ivan V.; Gotsko, Maxim D.; Sobenina, Lyubov' N.; Ushakov, Igor A.; Trofimov, Boris A.
• Is Part Of: Tetrahedron letters. Volume 84(2021)
• Publication Date: 2021-11-09
• Subjects: Acylethynylpyrroles -- TosMic -- Nucleophilic addition -- Acyltosylvinylpyrroles; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2021.153432
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Abstract: Uniquely functionalized at the double bond with tosyl and acyl substituents, E-2-(2-acyl-1-tosylvinyl)pyrroles, are chemo- and stereoselectively formed in up to 82% yield in reaction (Et3 N/MeCN) of tosylmethyl isocyanide (TosMIC) and available 2-(acylethynyl)pyrroles.