Prognostic Evaluation Based on Dual-Time 18F-FDG PET/CT Radiomics Features in Patients with Locally Advanced Pancreatic Cancer Treated by Stereotactic Body Radiation Therapy. (14th July 2022)

• Record Type: Journal Article
• Authors: Wang, Fei; Cheng, Chao; Ren, Shengnan; Wu, Zhongyi; Wang, Tao; Yang, Xiaodong; Zuo, Changjing; Yan, Zhuangzhi; Liu, Zhaobang
• Other Names: Yang Dong-Hua Academic Editor.
• Is Part Of: Journal of oncology. Volume 2022(2022)
• Publication Date: 2022-07-14
• Subjects: Oncology -- Research -- Periodicals; Tumors -- Periodicals; Neoplasms; Oncology -- Research; Tumors; Periodicals; Periodicals; 616.994
• DOI: 10.1155/2022/6528865
• Languages: English
• ISSNs: 1687-8450

Abstract

Abstract : Background . 18 F-FDG PET/CT is widely used in the prognosis evaluation of tumor patients. The radiomics features can provide additional information for clinical prognostic assessment. Purpose . Purpose is to explore the prognostic value of radiomics features from dual-time 18 F-FDG PET/CT images for locally advanced pancreatic cancer (LAPC) patients treated with stereotactic body radiation therapy (SBRT). Materials and Methods . This retrospective study included 70 LAPC patients who received early and delayed 18 F-FDG PET/CT scans before SBRT treatment. A total of 1188 quantitative imaging features were extracted from dual-time PET/CT images. To avoid overfitting, the univariate analysis and elastic net were used to obtain a sparse set of image features that were applied to develop a radiomics score (Rad-score). Then, the Harrell consistency index (C-index) was used to evaluate the prognosis model. Results . The Rad-score from dual-time images contains six features, including intensity histogram, morphological, and texture features. In the validation cohort, the univariate analysis showed that the Rad-score was the independent prognostic factor (p < 0.001, hazard ratio [HR]: 3.2). And in the multivariate analysis, the Rad-score was the only prognostic factor (p < 0.01, HR: 4.1) that was significantly associated with the overall survival (OS) of patients. In addition, according to cross-validation, the C-index of the prognosis model based on the Rad-score from dual-time images is better than the early and delayed images (0.720 vs. 0.683 vs. 0.583). Conclusion . The Rad-score based on dual-time 18 F-FDG PET/CT images is a promising noninvasive method with better prognostic value.