Dementia in Latin America: Paving the way toward a regional action plan. Issue 2 (20th November 2020)

• Record Type: Journal Article
• Authors: Parra, Mario Alfredo; Baez, Sandra; Sedeño, Lucas; Gonzalez Campo, Cecilia; Santamaría‐García, Hernando; Aprahamian, Ivan; Bertolucci, Paulo HF; Bustin, Julian; Camargos Bicalho, Maria Aparecida; Cano‐Gutierrez, Carlos; Caramelli, Paulo; Chaves, Marcia L. F.; Cogram, Patricia; Beber, Bárbara Costa; Court, Felipe A.; de Souza, Leonardo Cruz; Custodio, Nilton; Damian, Andres; de la Cruz, Myriam; Diehl Rodriguez, Roberta; Brucki, Sonia Maria Dozzi; Fajersztajn, Lais; Farías, Gonzalo A.; De Felice, Fernanda G.; Ferrari, Raffaele; de Oliveira, Fabricio Ferreira; Ferreira, Sergio T.; Ferretti, Ceres; Figueredo Balthazar, Marcio Luiz; Ferreira Frota, Norberto Anizio; Fuentes, Patricio; García, Adolfo M.; Garcia, Patricia J.; de Gobbi Porto, Fábio Henrique; Duque Peñailillo, Lissette; Engler, Henry Willy; Maier, Irene; Mata, Ignacio F.; Gonzalez‐Billault, Christian; Lopez, Oscar L.; Morelli, Laura; Nitrini, Ricardo; Quiroz, Yakeel T.; Guerrero Barragan, Alejandra; Huepe, David; Pio, Fabricio Joao; Suemoto, Claudia Kimie; Kochhann, Renata; Kochen, Silvia; Kumfor, Fiona; Lanata, Serggio; Miller, Bruce; Mansur, Leticia Lessa; Hosogi, Mirna Lie; Lillo, Patricia; Llibre Guerra, Jorge; Lira, David; Lopera, Francisco; Comas, Adelina; Avila‐Funes, José Alberto; Sosa, Ana Luisa; Ramos, Claudia; Resende, Elisa de Paula França; Snyder, Heather M.; Tarnanas, Ioannis; Yokoyama, Jenifer; Llibre, Juan; Cardona, Juan Felipe; Possin, Kate; Kosik, Kenneth S.; Montesinos, Rosa; Moguilner, Sebastian; Solis, Patricia Cristina Lourdes; Ferretti‐Rebustini, Renata Eloah de Lucena; Ramirez, Jeronimo Martin; Matallana, Diana; Mbakile‐Mahlanza, Lingani; Marques Ton, Alyne Mendonça; Tavares, Ronnielly Melo; Miotto, Eliane C; Muniz‐Terrera, Graciela; Muñoz‐Nevárez, Luis Arnoldo; Orozco, David; Okada de Oliveira, Maira; Piguet, Olivier; Pintado Caipa, Maritza; Piña Escudero, Stefanie Danielle; Schilling, Lucas Porcello; Rodrigues Palmeira, André Luiz; Yassuda, Mônica Sanches; Santacruz‐Escudero, Jose Manuel; Serafim, Rodrigo Bernardo; Smid, Jerusa; Slachevsky, Andrea; Serrano, Cecilia; Soto‐Añari, Marcio; Takada, Leonel Tadao; Grinberg, Lea Tenenholz; Teixeira, Antonio Lucio; Barbosa, Maira Tonidandel; Trépel, Dominic; Ibanez, Agustin;
• Is Part Of: Alzheimer's & dementia. Volume 17:Issue 2(2021)
• Page Start: 295
• Page End: 313
• Publication Date: 2020-11-20
• Subjects: biomarkers -- clinical trials -- dementia -- Latin America -- epidemiology -- evidence‐based recommendations -- genetics -- knowledge to action framework -- networking and translational research -- nonpharmacological interventions; Alzheimer's disease -- Periodicals; Alzheimer Disease -- Periodicals; Dementia -- Periodicals; Démence; Maladie d'Alzheimer; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.83
• DOI: 10.1002/alz.12202
• Languages: English
• ISSNs: 1552-5260

Abstract

Abstract: Across Latin American and Caribbean countries (LACs), the fight against dementia faces pressing challenges, such as heterogeneity, diversity, political instability, and socioeconomic disparities. These can be addressed more effectively in a collaborative setting that fosters open exchange of knowledge. In this work, the Latin American and Caribbean Consortium on Dementia (LAC‐CD) proposes an agenda for integration to deliver a Knowledge to Action Framework (KtAF). First, we summarize evidence‐based strategies (epidemiology, genetics, biomarkers, clinical trials, nonpharmacological interventions, networking, and translational research) and align them to current global strategies to translate regional knowledge into transformative actions. Then we characterize key sources of complexity (genetic isolates, admixture in populations, environmental factors, and barriers to effective interventions), map them to the above challenges, and provide the basic mosaics of knowledge toward a KtAF. Finally, we describe strategies supporting the knowledge creation stage that underpins the translational impact of KtAF.