O035 Evaluating the mental wellbeing of prostate cancer patients: initial results from the ongoing MIND-P cohort study. (22nd July 2022)

• Record Type: Journal Article
• Authors: Brunckhorst, O; Liszka, J; James, C; Fanshawe, J; Hammadeh, M; Williams, M; Thomas, R; Khan, S; Sheriff, M; Ahmed, H; Van Hemelrijck, M; Stewart, R; Dasgupta, P; Ahmed, K
• Is Part Of: British journal of surgery. Volume 109(2022)Supplement 4
• Publication Date: 2022-07-22
• Subjects: Surgery -- Periodicals; 617.005
• DOI: 10.1093/bjs/znac242.035
• Languages: English
• ISSNs: 0007-1323

Abstract

Abstract: Introduction: The impact of prostate cancer on an individual's mental wellbeing is becoming increasingly apparent. However, less is known about which patient, treatment and oncological factors are associated with poorer wellbeing outcomes. Methods: This ongoing prospective cohort study follows newly diagnosed patients for 1 year post cancer diagnosis (NCT04647474). Participants were recruited across eight hospitals with validated questionnaires completed at 3-monthly intervals. Wellbeing scores were compared between treatment groups with a univariate logistic regression conducted to evaluate a composite outcome of developing any significant mental wellbeing issue (depressive or anxiety symptoms, fear of cancer recurrence, body image or masculine self-esteem) against other patient and oncological factors. Results: Of 198 participants recruited, 134 have undergone at least 3 months follow up and were included in the analysis. Mental wellbeing issues were common with probable depression and anxiety in 11.2% and 9.7% of participants respectively. Overall, a third (33.5%) of participants developed at least one significant mental wellbeing issue. No differences were seen between treatment group mental wellbeing mean scores. However, younger age (OR 0.95, p=0.028) and Black or African ethnicity (OR 5.41, p=0.008) were significant patient factors. Additionally, all baseline mental wellbeing symptoms scores were significantly associated, with depressive and anxiety (both OR 1.36, p<0.001) symptoms important predictors. Conclusion: We demonstrate the significant incidence of mental wellbeing issues during the initial prostate cancer follow up. Additionally, patient factors and baseline mental wellbeing scores appear to be associated with poorer outcomes and should be considered during prostate cancer follow up. Take-home message: Mental wellbeing issues are common post a prostate cancer diagnosis. It is therefore important to consider associative features for their development such as younger age and ethnicity during cancer follow up to improve identification of these issues during care.