Warfarin-Induced Skin Necrosis Following Heparin-Induced Thrombocytopenia. Issue 1 (1st January 2016)

• Record Type: Journal Article
• Authors: Fawaz, Bilal; Candelario, Nicole M.; Rochet, Nicole; Tran, Connie; Brau, Cristina
• Is Part Of: Proceedings. Volume 29:Issue 1(2016)
• Page Start: 60
• Page End: 61
• Publication Date: 2016-01-01
• Subjects: Medicine -- Periodicals; Medicine; Medicine -- Periodicals; Periodicals; Electronic journals; 616.005
• DOI: 10.1080/08998280.2016.11929362
• Languages: English
• ISSNs: 0899-8280

Abstract

Abstract : Anticoagulants, such as heparin and warfarin, are commonly used in the treatment and prevention of thromboembolic events. The risk of developing warfarin-induced skin necrosis (WISN) with warfarin is reported to be <1%. However, the risk of WISN may be increased with the initiation of warfarin in the setting of heparin-induced thrombocytopenia and thrombosis syndrome (HITT). WISN can lead to catastrophic tissue necrosis requiring amputations and mass debridement. This report describes a case of WISN following HITT and discusses the appropriate medical management of patients with HITT to avoid secondary WISN.