Personalized Treatment of Heart Failure with Biomarker Guidance Using a Novel Disease Severity Score. Issue 2 (1st April 2017)

• Record Type: Journal Article
• Authors: Vasudevan, Anupama; Jazi, Hourossadat Hashemi; Won, Jane I.; Ball, Timothy; Patankar, Gautam R.; Sarmast, Syed A.; Shin, Hyun Joon; Mccullough, Peter A.
• Is Part Of: Proceedings. Volume 30:Issue 2(2017)
• Page Start: 139
• Page End: 142
• Publication Date: 2017-04-01
• Subjects: Medicine -- Periodicals; Medicine; Medicine -- Periodicals; Periodicals; Electronic journals; 616.005
• DOI: 10.1080/08998280.2017.11929561
• Languages: English
• ISSNs: 0899-8280

Abstract

Abstract : We propose a novel Myocardial Injury Summary Score (MISS) integrating the 4 biomarkers suggested by the 2013 American College of Cardiology/American Heart Association guidelines for management of heart failure. In this case series, we examined 4 heart failure patients who received treatment guided by the biomarker results and 4 patients who received routine clinical management with no information about the biomarkers. Most of the patients receiving biomarker-guided management had medications adjusted based on the biomarker values, while no changes were recommended for patients in the biomarker-blinded category. This case series suggests that biomarker-guided therapy with serial biomarker values leads to timely therapeutic adjustment and that biomarker values as a composite score can be used effectively to measure the severity of heart failure.