Chronic neutrophilic leukemia. Issue 1 (2nd January 2018)

• Record Type: Journal Article
• Authors: Bredeweg, Arthur; Burch, Micah; Krause, John R.
• Is Part Of: Proceedings. Volume 31:Issue 1(2018)
• Page Start: 88
• Page End: 89
• Publication Date: 2018-01-02
• Subjects: Chronic neutrophilic leukemia -- CSF3R -- myeloproliferative disorder -- RUNX1 -- SETBP1 -- SRSF2; Medicine -- Periodicals; Medicine; Medicine -- Periodicals; Periodicals; Electronic journals; 616.005
• DOI: 10.1080/08998280.2017.1400300
• Languages: English
• ISSNs: 0899-8280

Abstract

ABSTRACT: Chronic neutrophilic leukemia is a rare myeloproliferative disorder characterized by a sustained peripheral blood neutrophilia, absence of the BCR/ABL oncoprotein, bone marrow hypercellularity with less than 5% myeloblasts and normal neutrophil maturation, and no dysplasia. This leukemia has been associated with mutations in the colony-stimulating factor 3 receptor (CSF3R) that may activate this receptor, leading to the proliferation of neutrophils that are the hallmark of chronic neutrophilic leukemia. We present a case of chronic neutrophilic leukemia and discuss the criteria for diagnosis and the significance of mutations found in this leukemia.