Acute kidney injury and undiagnosed immunoglobulin A nephropathy after dabigatran therapy. Issue 3 (3rd July 2018)

• Record Type: Journal Article
• Authors: Jansky, Laurie; Mukkamala, Pallavi; Jebakumar, Deborah; Rao, Arundhati; Goldson, Tove M.; Forjuoh, Samuel N.
• Is Part Of: Proceedings. Volume 31:Issue 3(2018)
• Page Start: 321
• Page End: 323
• Publication Date: 2018-07-03
• Subjects: Acute kidney injury -- dabigatran -- hematuria -- immunoglobulin A nephropathy; Medicine -- Periodicals; Medicine; Medicine -- Periodicals; Periodicals; Electronic journals; 616.005
• DOI: 10.1080/08998280.2018.1463036
• Languages: English
• ISSNs: 0899-8280

Abstract

ABSTRACT: Dabigatran, a new oral anticoagulant, is a direct thrombin inhibitor used as an alternative to warfarin to reduce the risk of stroke and systemic embolism with nonvalvular atrial fibrillation. We report a case of a man who resumed dabigatran after 6 weeks of prior therapy and began experiencing hematuria with worsening kidney function. Renal biopsy with immunofluorescence and electron microscopy showed mesangial deposits consistent with immunoglobulin A nephropathy. With discontinuation of dabigatran and addition of methylprednisolone, the gross hematuria cleared and urine output improved.