Early histological changes of bronchopulmonary dysplasia and pulmonary hypertension may precede clinical diagnosis in preterm infants. (August 2022)

• Record Type: Journal Article
• Authors: Stone, Amelia; Poulik, Janet; Koussa, Sara; Xin, Yuemin; Sharma, Amit; Sood, Beena G.
• Is Part Of: Early human development. Volume 171(2022)
• Publication Date: 2022-08
• Subjects: Bronchopulmonary dysplasia -- BPD -- Pulmonary hypertension -- PH -- Histology -- Histological -- Premature -- Extremely premature -- Autopsy -- Postmortem -- Clinical definition; Fetus -- Periodicals; Neonatology -- Periodicals; Prenatal influences -- Periodicals; 612.65
• DOI: 10.1016/j.earlhumdev.2022.105612
• Languages: English
• ISSNs: 0378-3782

Abstract

Abstract: Bronchopulmonary Dysplasia (BPD), the commonest complication of prematurity, is defined by treatment with oxygen for ≥28 days. Pulmonary hypertension (PH) often coexists with BPD and is associated with increased mortality. In 42 autopsies, histological changes of BPD and PH were demonstrated in 25 % and 65 % respectively of preterm infants <28 days of age, highlighting the need for early diagnosis and treatment. Highlights: Bronchopulmonary Dysplasia (BPD) is the commonest complication of prematurity. BPD is clinically defined by treatment with oxygen for ≥28 days. Pulmonary hypertension (PH) often coexists with BPD and increases mortality. We report histologic BPD and PH in preterm infants treated with oxygen for <28 days. Current clinical definitions do not allow for early diagnosis of BPD and PH.