COVID-19 in the elderly people and advances in vaccination approaches. Issue 12 (1st December 2020)

• Record Type: Journal Article
• Authors: Dhama, Kuldeep; Patel, Shailesh Kumar; Natesan, Senthilkumar; Vora, Kranti Suresh; Iqbal Yatoo, Mohd; Tiwari, Ruchi; Saxena, Shailendra K; Singh, Karam Pal; Singh, Rajendra; Malik, Yashpal Singh
• Is Part Of: Human vaccines & immunotherapeutics. Volume 16:Issue 12(2020)
• Page Start: 2938
• Page End: 2943
• Publication Date: 2020-12-01
• Subjects: SARS-CoV-2 -- covid-19 -- elderly people -- vaccine; Vaccines -- Periodicals; 615.372
• DOI: 10.1080/21645515.2020.1842683
• Languages: English
• ISSNs: 2164-5515

Abstract

ABSTRACT: The rapid worldwide spread of the COVID-19 pandemic, caused by the newly emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in tens of millions of infections and over one million deaths. SARS-CoV-2 infection affects all age groups; however, those over 60 years old are affected more severely. Moreover, pre-existing co-morbidities result in higher COVID-19-associated mortality in the geriatric population. This article highlights the associated risk factors of SARS-CoV-2 infection in older people and progress in developing COVID-19 vaccines, especially for efficient vaccination of the older population. There is also a summary of immunomodulatory and immunotherapeutic approaches to ameliorate the outcome of COVID-19 in older individuals.