Association of VEGFA, TIMP-3, and IL-6 gene polymorphisms with predisposition to optic neuritis and optic neuritis with multiple sclerosis. (2nd January 2021)

• Record Type: Journal Article
• Authors: Punyte, Vaida; Vilkeviciute, Alvita; Gedvilaite, Greta; Kriauciuniene, Loresa; Liutkeviciene, Rasa
• Is Part Of: Ophthalmic genetics. Volume 42:Number 1(2021)
• Page Start: 35
• Page End: 44
• Publication Date: 2021-01-02
• Subjects: Optic neuritis -- multiple sclerosis -- VEGFA -- TIMP-3 -- IL-6; Eye -- Diseases -- Genetic aspects -- Periodicals; Eye Diseases -- genetics -- Periodicals; Eye Diseases -- in infancy & childhood -- Periodicals; 617.7
• DOI: 10.1080/13816810.2020.1839916
• Languages: English
• ISSNs: 1381-6810

Abstract

ABSTRACT: Background: The etiology of the inflammatory ON is multifactorial. Much attention is paid to the inflammatory and immune processes that are likely to contribute to the demyelination and MS development. IL-6, VEGFA, and TIMP-3 genes are thought to be involved in the inflammatory processes and manifestation of CNS demyelination, so we aimed to determine the relationship between VEGFA rs1413711, TIMP-3 rs9621532, IL-6 rs1800796 gene polymorphisms and ON, and ON with MS. Materials and methods: Patients with ON, ON with MS, and a random sample of healthy population were enrolled. The genotyping of VEGFA rs1413711, TIMP-3 rs9621532, and IL-6 rs1800796 polymorphisms was carried out using the real-time polymerase chain reaction method. Results: T/C and C/C genotypes of VEGFA rs1413711 were associated with about threefold increased odds of developing ON in the dominant and codominant models. Each allele C at VEGFA rs1413711 was associated with 1.7-fold increased odds of ON development. IL-6 rs1800796 allele C was more frequent in the ON with MS group compared to the control: 17.6% vs. 7.5%, respectively ( p = .040). No statistically significant associations were found between TIMP-3 rs9621532 and the ON development. Conclusion: VEGFA: rs1413711 is associated with the ON development.