The relationship between B7 homologous 1 with interleukin-4, interleukin-17 and interferon gamma in patients with allergic rhinitis. (3rd August 2019)

• Record Type: Journal Article
• Authors: Nasiri Kalmarzi, Rasoul; Fakhimi, Roozbeh; Manouchehri, Farhad; Ataee, Pedram; Naleini, Nima; Babaei, Erfan; Azadi, Namamali; Rabeti, Kasra; Kooti, Wesam
• Is Part Of: Expert review of clinical immunology. Volume 15:Number 8(2019)
• Page Start: 897
• Page End: 901
• Publication Date: 2019-08-03
• Subjects: B7 homologous 1 -- Interleukin-4 -- Interleukin-17 -- Interferon gamma -- allergic rhinitis; Clinical immunology -- Periodicals; 616.079
• DOI: 10.1080/1744666X.2019.1637256
• Languages: English
• ISSNs: 1744-666X

Abstract

ABSTRACT: Background : The etiology of allergic rhinitis includes an increase in cytokine levels, including IL- 4, IL-13, IL-17, and reduction in B7 homologous 1 (B7-H1) or programmed cell death-1 ligand-1 (PD-L1), a new member of the CD28: B7 stimulant molecule family. The aim of this study was to determine the relationship between cytokines and PD-L1. Methods : In this experimental study, 80 patients with allergic rhinitis were enrolled according to inclusion and exclusion criteria. The severity and stage of the disease were determined by a specialist physician. A 5 cc venous blood sample was collected from the patients. IL-4, IL-17, INFγ and PD-L1 were measured using ELISA technique. Results : There was a significant correlation between SPD-L1 and INFγ, IL-4 and IL-17 in allergic rhinitis patients (P < 0.05). Statistical analysis based on the severity of the disease (Mild, Moderate and Severe) showed a significant positive correlation between the SPD-L1 and INFγ in all three levels (P < 0.001). There was also a significant negative correlation between SPD-L1 and two cytokines IL-4 and IL-17 (P < 0.001). Conclusion : PD-L1 may have a protective role against allergic rhinitis, although the precise mechanism requires further detailed studies.