Mammalian mitochondrial DNA replication and mechanisms of deletion formation. (1st November 2020)

• Record Type: Journal Article
• Authors: Falkenberg, Maria; Gustafsson, Claes M.
• Is Part Of: Critical reviews in biochemistry and molecular biology. Volume 55:Number 6(2020)
• Page Start: 509
• Page End: 524
• Publication Date: 2020-11-01
• Subjects: Mitochondrion -- DNA replication -- deletion -- DNA helicase -- DNA polymerase; Biochemistry -- Periodicals; Molecular biology -- Periodicals; Biochemistry -- Periodicals; Molecular Biology -- Periodicals; Review Literature -- Periodicals; 572
• DOI: 10.1080/10409238.2020.1818684
• Languages: English
• ISSNs: 1040-9238

Abstract

Abstract: Mammalian mitochondria contain multiple copies of a circular, double-stranded DNA genome (mtDNA) that codes for subunits of the oxidative phosphorylation machinery. Mutations in mtDNA cause a number of rare, human disorders and are also associated with more common conditions, such as neurodegeneration and biological aging. In this review, we discuss our current understanding of mtDNA replication in mammalian cells and how this process is regulated. We also discuss how deletions can be formed during mtDNA replication.