Serum Cortistatin Levels in Patients with Ocular Active and Ocular Inactive Behçet Disease. (18th May 2020)

• Record Type: Journal Article
• Authors: Balbaba, Mehmet; Ulaş, Fatih; Postacı, Sevinç Arzu; Öz, Burak; Aydın, Süleyman
• Is Part Of: Ocular immunology and inflammation. Volume 28:Number 4(2020)
• Page Start: 601
• Page End: 605
• Publication Date: 2020-05-18
• Subjects: Behçet disease -- Behçet disease ocular attack score 24 -- cortistatin -- C-reactive protein -- erythrocyte sedimentation rate -- neutrophil-lymphocyte ratio; Eye -- Diseases -- Immunological aspects -- Periodicals; Eye -- Inflammation -- Periodicals; 617.7
• DOI: 10.1080/09273948.2019.1610461
• Languages: English
• ISSNs: 0927-3948

Abstract

ABSTRACT: Purpose: To evaluate serum cortistatin (CST) levels in patients with ocular active and ocular inactive Behçet disease (BD) and its relationship with disease activity. Methods: 24 BD patients with ocular active, 24 BD patients with ocular inactive patients and 24 healthy control subjects were included in the study. Results: In ocular active and ocular inactive BD patients and healthy control subjects, the mean serum CST levels were 4.38 ± 1.63ng/ml, 5.46 ± 1.81ng/ml and 7.56 ± 1.73ng/ml, respectively. ESR, serum CRP, CST levels and NLR were significantly different between the groups (p < 0.001 for all). The CST levels were similar between ocular active and inactive BD patient groups (p = 0.197). ESR, CRP and NLR were significantly higher in ocular active BD patients compared to ocular inactive BD patients and healthy control subjects (p < 0.05 for all). Conclusion: Serum CST level was significantly lower in BD patients. CST may be a neuropeptide that plays a role in the pathogenesis of BD.