Intertwined reproductive endocrinology: Puberty and polycystic ovary syndrome. (October 2020)

• Record Type: Journal Article
• Authors: Witchel, Selma Feldman; Plant, Tony M.
• Is Part Of: Current opinion in endocrine and metabolic research. Volume 14(2020)
• Page Start: 127
• Page End: 136
• Publication Date: 2020-10
• Subjects: Puberty -- Polycystic ovary syndrome -- Hyperandrogenism -- Testosterone -- Gonadotropins; Endocrine glands -- Diseases -- Periodicals; Metabolism -- Disorders -- Periodicals; Endocrine System Diseases; Metabolic Diseases; Endocrine glands -- Diseases; Metabolism -- Disorders; Periodical; Electronic journals; Periodicals; Electronic journals; 616.4
• DOI: 10.1016/j.coemr.2020.07.004
• Languages: English
• ISSNs: 2451-9650

Abstract

Abstract: Polycystic ovary syndrome (PCOS) is a heterogeneous familial disorder often emerging during the peri-pubertal years concomitantly with the onset of gonadarche and adrenarche. Both gonadarche and PCOS reflect functional changes in the hypothalamic–pituitary––ovarian axis. During this transition, normal girls manifest features consistent with PCOS such as irregular menses, mild hyperandrogenism, and multifollicular ovary morphology. Themes common to puberty and PCOS, neuroendocrine features, androgen exposure, and insulin sensitivity, will be considered to address the possibility that PCOS interferes with the normal pubertal transition.