A case of oral lichenoid reaction during nivolumab therapy. Issue 6 (November 2020)
- Record Type:
- Journal Article
- Title:
- A case of oral lichenoid reaction during nivolumab therapy. Issue 6 (November 2020)
- Main Title:
- A case of oral lichenoid reaction during nivolumab therapy
- Authors:
- Yamanaka, Shigeki
Nakao, Kazumasa
Ninomiya, Aya
Watanabe, Takuma
Inoue, Yu
Kashiwagi, Marina
Fukuhara, Shizuko
Asai, Keita
Yamaguchi, Akihiko
Kataoka, Tatsuki
Bessho, Kazuhisa - Abstract:
- Abstract: Nivolumab is a monoclonal antibody drug targeting the programmed cell death receptor-1 (PD-1). It has been shown to improve immune responses and marked clinical efficacy to treat many cancers such as advanced melanoma and non-small-cell lung cancer. However, immune-related adverse events (irAEs) in multiple organ systems are a well-recognized consequence of immunotherapy. Previous reports show that oral lichenoid reactions (OLRs) have been observed in patients receiving anti-programmed death cell receptor-1 therapy such as nivolumab. Here we report a case of OLR presenting with white lesions associated with nivolumab therapy. A 26-year-old woman was administered nivolumab for stage IIIC melanoma of the lower back and developed asymptomatic white lesions on her buccal mucosa, seven weeks after the initial nivolumab therapy. She was diagnosed with OLR based on these clinical and histopathological features, which were similar to graft-versus-host reactions. The patient responded well to topical dexamethasone and she continued nivolumab therapy.
- Is Part Of:
- Journal of oral and maxillofacial surgery, medicine, and pathology. Volume 32:Issue 6(2020)
- Journal:
- Journal of oral and maxillofacial surgery, medicine, and pathology
- Issue:
- Volume 32:Issue 6(2020)
- Issue Display:
- Volume 32, Issue 6 (2020)
- Year:
- 2020
- Volume:
- 32
- Issue:
- 6
- Issue Sort Value:
- 2020-0032-0006-0000
- Page Start:
- 521
- Page End:
- 524
- Publication Date:
- 2020-11
- Subjects:
- Nivolumab -- Programmed cell death receptor-1 (PD-1) -- Immune-related adverse events (irAEs) -- Oral lichenoid reaction (OLR)
Mouth -- Surgery -- Periodicals
Face -- Surgery -- Periodicals
Maxilla -- Surgery -- Periodicals
Oral medicine -- Periodicals
Mouth -- Diseases -- Pathogenesis -- Periodicals
Surgery, Oral -- Periodicals
Oral Medicine -- Periodicals
Pathology, Oral -- Periodicals
Face -- Surgery
Maxilla -- Surgery
Mouth -- Diseases -- Pathogenesis
Mouth -- Surgery
Oral medicine
Electronic journals -- Sciences
Electronic journals -- Medicine
Periodicals
617.522059 - Journal URLs:
- http://www.sciencedirect.com/science/journal/22125558 ↗
http://www.sciencedirect.com/ ↗ - DOI:
- 10.1016/j.ajoms.2020.07.018 ↗
- Languages:
- English
- ISSNs:
- 2212-5566
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 22636.xml